Joan Beal writes about endothelial dysfunction in MS. http://ccsviinms.blogspot.com/2017/05/ms-is-vascular.html

CCSVI Alliance additional notes:
Authored by Dr Alexander & Dr Minagar "Emerging Roles of Endothelial Cells in Multiple Sclerosis Pathophysiology and Therapy"
Quote: "Basic scientific and clinical studies now support contributions of vascular and endothelial cell stress and apoptosis as significant features of MS and help explain how blockade of leukocyte binding and transendothelial extravasation of activated immune cells across the MS-inflamed cerebral microvasculature and restitution of endothelial barrier function represent important goals of MS treatment. Such approaches can achieve significant reductions in MS disease activity and progression, but carry risks from interference with immune surveillance".

Disorders, habits and unavoidable life events (trauma, structural/mechanical abnormalities) can contribute to endothelial dysfunction. https://www.verywell.com/endothelial-dysfunction-1746344

MS is caused by a breakdown of cerebral endothelial cells. The loss of these vascular cells, which line all 60,000 miles of our blood and ...