Damage to the cerebellum in the MS brain is known to affect coordination, movement, speech and cognitive thinking. It will be interesting to see how new research on the cerebellum will link to the MS brain.
"A study in rodents found that the brain's cerebellum -- known to play a role in motor coordination -- also helps control the brain's reward circuitry. Researchers found a direct neural connection from the cerebellum to the ventral tegmental area (a brain area long known to be involved in reward processing and encoding). The findings shed light on the brain circuits critical to the affective and social dysfunction seen across multiple psychiatric disorders."
https://www.sciencedaily.com/releases/2019/01/190117142151.htm

A study in rodents found that the brain's cerebellum -- known to play a role in motor coordination -- also helps control the brain's reward circuitry. Researchers found a direct neural connection from the cerebellum to the ventral tegmental area (a brain area long known to be involved in reward proc...