Vascular Health does start on a cellular level &
Magnesium does play a major role!

All risk factors for cardiovascular diseases (hypertension, high total cholesterol, high homocysteine, high C-reactive protein) can be result of low Magnesium status. Recent studies have shown that anxiety and/or depression (well documented symptoms of Mg deficiency) can predict heart disease very precisely.

As a co-factor Mg provides much needed ATP energy for heart muscle cells and its levels affect cardiac excitability, contraction, and conduction. Low Mg : high Ca in blood vessel muscle cells cause them to contract, resulting e.g. in high blood pressure.

Magnesium rules! Because it is the first responder to physical (injury/toxins etc.) and/or mental stress and its levels determine vasoconstriction or vasodilation. Sufficient Mg levels inside muscle cells, produce a relaxing or vasodilating effect and insufficient Mg concentrations inside muscle cells does cause vasoconstricting. That’s how not just the human body works. Ask a veterinarian you trust!

Magnesium protects the vascular system from negative effects of excess calcium by blocking calcium entry into the body tissue of the heart- & smooth vascular muscle cells and does naturally equilibrating blood pressure in arteries AND veins. Magnesium acts as an anti-arrhythmic agent as well. It limits intracellular calcium overload triggered during myocardial ischemia. Imbalance of Mg, Ca and K can cause endothelial dysfunction and stenosed veins/blood vessels in general.

Stenosed veins/blood vessels don't come from Mars and they are not God given either but a man made mess/health condition!

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“Endothelial cells and magnesium: implications in atherosclerosis”, by Jeanette A. M. MAIER , Dipartimento di Scienze Cliniche L. Sacco, Universita di Milano, Via G.B. Grassi 74, Milano, Italy

ABSTRACT

There is no doubt that the functional and structural integrity of the endothelium is critical in maintaining vascular homoeostasis and in preventing atherosclerosis. In the light of epidemiological and experimental studies, magnesium deficiency is emerging as an inducer of endothelial dysfunction. In particular, data on the effects of low extracellular magnesium on cultured endothelial cells reinforce the idea that correcting magnesium homoeostasis might be a helpful and inexpensive intervention to prevent and treat endothelial dysfunction and, consequently, atherosclerosis.

full paper: http://www.clinsci.org/cs/122/0397/1220397.pdf