Oxidative tissue injury in multiple sclerosis is only partly reflected in experimental disease models. Acta Neuropathol. 2014
"...In the present study, we show notable differences between MS and its different animal models regarding microglial activation, oxidative injury and iron accumulation in the undiseased CNS as well as within active inflammatory demyelinating lesions (Table 2). We found that the expression of enzymes involved in oxygen and nitric oxide radical production in cells with microglia or macrophage phenotype is different depending on the primary nature of the inflammatory response...."
Full paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102830/pdf/401_2014_Article_1263.pdf