How do Magnesium, Iron, & Inflammation relate? Proteins! --- "Major targets of iron-induced protein oxidative damage in frataxin-deficient yeasts are magnesium-binding proteins." Free Radic Biol Med. 2008

"...As a general conclusion, we propose that magnesium bound to proteins is replaced by chelatable iron when this metal accumulates. This mechanism explains selective protein oxidation and provides clues for better understanding of iron-overloading pathologies."
learn more: http://www.sciencedirect.com/science/article/pii/S0891584908000294

Iron accumulation has been associated with several pathological conditions such as Friedreich ataxia. This human disorder is caused by decreased expression of frataxin. Iron-overload triggers oxidative stress, but the main targets of such stress are not known. In yeast cells lacking the frataxin ort...