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Tuesday, February 21, 2017 8:29 PM | Venöse Multiple Sklerose, CVI & SVI, CCSVI Volg link
Prominent Perivenular Spaces in Multiple Sclerosis as a Sign of Perivascular Inflammation in Primary Demyelination

Summary: In this study, we describe prominent perivenular spaces as a sign that is seen on high-resolution (512 × 512) transverse T2-weighted MR images in patients with multiple sclerosis. The observed widening of perivenular space is depicted as a stringlike hyperintensity projecting radially and aligned with multiple sclerosis lesions (usually small), following the course and configuration of deep venular structures. This widening may be an important sign in differentiating primary (ie, in multiple sclerosis) from secondary causes of demyelination.

Perivascular inflammation is a critical event in the pathogenesis and evolution of multiple sclerosis lesions. We describe prominent perivenular spaces that appear to be associated with and may be useful as a sign in differentiating multiple sclerosis from other white matter diseases.
aDepartment of Radiology, New York University School of Medicine, New York, NY
bDepartment of Neurology, Hospital for Joint Disease, New York University School of Medicine, New York, NY
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