Magnesium Sulfate for the Treatment of Eclampsia, Stroke. 2009

“...Conclusion
MgSO4 has been shown to be an effective treatment option for the prevention of eclampsia. Its mechanism of action is likely multi-factorial, encompassing both vascular and neurological mechanisms. Being a calcium antagonist, its effect on vascular smooth muscle to promote relaxation and vasodilation may have a role in lowering total peripheral vascular resistance. In addition, MgSO4 may have an effect on the cerebral endothelium to limit vasogenic edema by decreasing stress fiber contraction and paracellular permeability via calcium-dependent second messenger systems such as MLC kinase. Lastly, MgSO4 may also act centrally to inhibit NMDA receptors, providing anticonvulsant activity by increasing the seizure threshold. A more complete understanding of the effects of MgSO4 will likely promote safer and more effective treatments of eclampsia.”
full paper: http://stroke.ahajournals.org/content/40/4/1169