Magnesium protects cognitive functions and synaptic plasticity in streptozotocin-induced sporadic Alzheimer's model., 2014

"...We conclude that magnesium treatment protects cognitive function and synaptic plasticity by inhibiting GSK-3ß in sporadic AD model rats, which suggests a potential role for magnesium in AD therapy...

...In summary, we found that simultaneous intraperitoneal injections of magnesium sulfate significantly enhanced the brain magnesium levels, improved synaptic efficacy, and prevented memory and learning impairments through modifications of synaptic proteins and Tau phosphorylation in ICV-STZ rats. Our findings provide novel insights suggesting that magnesium treatment at the early stage may decrease the risk for cognitive impairment in AD."
Full paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182554/