Exposure to excessive oral vitamin D in youth: a risk factor for celiac disease in later life?, Journal of Allergy and Asthma, 2015

„Conclusion
A wealth of evidence supports the hypothesis that significant consumption of oral vitamin D among the young is a risk factor for inducing celiac disease. Exposing infants and toddlers to large doses of oral vitamin D has been found to be a risk factor for inducing allergic diseases including atopic dermatitis and asthma both of which have a high comorbidity with celiac. Celiac is an allergic disease using a broad definition of allergic disease and elevations in Th2 cytokines have been shown to be fundamental to celiac disease. As Th2 cytokines are upregulated by oral vitamin D, this suggests that oral vitamin D could be a risk factor in inducing celiac disease as well. The case of Williams syndrome and its spikes in 1,25-dihydroxy vitamin D and high comorbidity with celiac further supports this hypothesis. Epidemiologically, the countries that have the most aggressive fortification and supplementation policies for vitamin D are the countries where the prevalence of celiac is greatest. In addition the increase in supplementation and fortification of vitamin D in recent decades in the United States corresponds with the increasing rates of celiac disease seen in the United States during the same time period. Also the Swedish celiac disease epidemic starting around 1984 corresponds well to implementation of widespread vitamin D fortification in Sweden dating from 1983. Additional research will be needed to confirm this hypothesis.“

Full paper: http://www.hoajonline.com/allergyasthma/2054-9873/2/2