“Vitamin D” MythBuster – 2013 Johns Hopkins University came up with the conclusion that there is no clinical benefit having Storage-D Hormone levels greater than 21ng/dL, -- NO BENEFIT!

“Relationship between 25-Hydroxyvitamin D and All-cause and Cardiovascular Disease Mortality.”

Abstract

Background
Observational studies have suggested a strong relationship between 25(OH)D and all-cause and cardiovascular disease mortality. A few studies also have described a nonlinear trend for this relationship in population subgroups, but less is known about this relationship in healthy adults. We examined the presence of a nonlinear relationship between 25(OH)D and all-cause and cardiovascular disease mortality among healthy adults.

Methods
We examined 10,170 participants (=18 years of age) using National Health and Nutrition Examination Survey data (2001-2004) combined with National Death Index for vital status information through December 2006. Cox proportional hazard models with spline (single knot at population median of 25[OH]D) were fit to estimate hazard ratios (HRs) for all-cause and cardiovascular disease mortality for each 10-unit increase in serum 25(OH)D. Models were adjusted for demographic and conventional cardiovascular disease risk factors.

Results
Mean age of study participants was 46.6 (20.5) years, while median (interquartile range) 25(OH)D was 21 (15-27) ng/mL. After a median follow-up of 3.8 years (range 2.8-4.9), 509 all-cause and 184 cardiovascular diseases-related deaths were observed. In univariate analysis, 25(OH)D decreased hazards of all-cause (HR 0.59; 95% confidence interval [CI], 0.45-0.77) and cardiovascular disease (HR 0.56; 95% CI, 0.38-0.82) mortality below but not above its population median. In adjusted models, 25(OH)D retained the inverse association for all-cause (HR 0.54; 95% CI, 0.35-0.84) and cardiovascular disease (HR 0.50; 95% CI, 0.26-0.98) mortality below but not above its population median.

Conclusions
We found an inverse association between 25(OH)D and all-cause and cardiovascular disease mortality in healthy adults with serum 25(OH)D levels of =21 ng/mL. Clinical trials for the primary prevention of cardiovascular disease with 25(OH)D supplementation may target healthy adults with serum 25(OH)D levels of =21 ng/mL to validate these findings.

Full paper: The American Journal of Medicine, 2013; DOI: http://www.amjmed.com/article/S0002-9343(13)00084-3/fulltext

Science Daily: “Vitamin D: More may not be better; Benefits in healthy adults wear off at higher doses, research suggests”
Summary:

In recent years, healthy people have been bombarded by stories in the media and on health websites warning about the dangers of too-low vitamin D levels, and urging high doses of supplements to protect against everything from hypertension to hardening of the arteries to diabetes. But new research finds that blood levels of the so-called "sunshine vitamin" that are higher than the top of the range suggested by the Institute of Medicine confer no additional benefit. This finding, combined with results of a previous study noting potential harm from higher vitamin D levels in healthy people, has urged investigators to prescribe caution.
https://www.sciencedaily.com/rel.../2013/05/130501192929.htm