"Why Most Clinical Research is Not Useful"
By John P. A. Ioannidis -

An interesting article that includes the importance of patient-centered research...

"Patient Centeredness"

"Useful research is patient centered [20]. It is done to benefit patients or to preserve health and enhance wellness, not for the needs of physicians, investigators, or sponsors. Useful clinical research should be aligned with patient priorities, the utilities patients assign to different problems and outcomes, and how acceptable they find interventions over the period for which they are indicated. Proposed surrogate outcomes used in research need to closely correlate with real patient-relevant outcomes for patients in the clinic."

"Conclusion:"

"Overall, not only are most research findings false, but, furthermore, most of the true findings are not useful. Medical interventions should and can result in huge human benefit. It makes no sense to perform clinical research without ensuring clinical utility. Reform and improvement are overdue."

http://journals.plos.org/plosmedicine/article%3Fid%3D10.1371/journal.pmed.1002049

Most clinical research findings are false. As for the few studies with results that are true, well, here’s more bad news. Most of those findings are useless. These are but two of the bold statements made by Dr. John Ioannidis in a recent paper in PLoS Medicine.