Dr Flavia Nelson, University of Texas, poster presentation at the annual meeting of the American Neurological Association....
"Sulcal Measurements May Infer MS Cognitive Deficit
Imaging studies could be a noninvasive surrogate"

Asked for her opinion of the study, Jennifer Graves, MD, PhD, of the University of California, San Francisco, told MedPage Today: "Dr. Nelson indicated that trying to generate the sulcal cerebrospinal fluid volumes might have more utility than ventricular volume as a surrogate of atrophy.
"What happens in brain atrophy is that the solci become more pronounced and fill with spinal fluid, and in viewing this with imaging, you have a surrogate for tissue loss in the brain," Graves explained.
http://www.medpagetoday.com/masters-of-medicine/neurology-mastery-in-ms/60878?xid=NL_MBCustom_2016-10-19&eun=g330925d0r

Imaging studies could be a noninvasive surrogate