Buffalo Neuroimaging Analysis Center

100 High Street ? Buffalo, NY 14203

TEL: 716.859.7040 ? FAX: 716.859.7066

www.BNAC.net

December 10, 2010

Dear Friend,

Over the past two years our research team has been studying this, possibly paradigm-shifting and certainly controversial, theory.

We want to know:

• Are constricted veins the cause, consequence, or important contributing factors of multiple sclerosis (MS)?


• Are people with CCSVI more susceptible to developing MS?


• Is there is a relationship between blocked veins and MS progression?


• If CCSVI is present, is treatment needed?


• Or, is CCSVI just another MS theory that will fizzle under the careful scrutiny of scientific research, like so many others have over the years?

We believe that BNAC is uniquely qualified to find these answers for two reasons. First, we have an experienced team of researchers who have been working together for several years studying this theory. Second, they have used the most advanced technology to create one of the world’s largest and most complete data bank of venous anomalies as they relate to MS. It contains clinical, MRI, genetic, ultrasound and environmental information from over 1,000 people who have participated in our CCSVI studies.

Beyond our basic CCSVI research, a few months ago we joined University at Buffalo neurosurgeons to develop the first IRB approved CCSVI Treatment Placebo-Controlled Clinical Trial. In June, ten people with MS who met two or more criteria underwent angioplasty treatments as part of Phase 1 of our Treatment Study. This phase tested the safety of the balloon angioplasty treatment procedure. We are now enrolling 20 more participants in Phase 2 of the study, to begin later this year. This phase will be blinded to test the placebo effect and, like the initial ten subjects, these subjects will be evaluated periodically over six months. Our costs for this trial alone are over $700,000.

As you may know, this research has generated great passion among all sectors of the MS community. Unlike any other MS research, securing funding for this research will depend mostly on gifts from people like you. I am writing to you today because we need your support for this CCSVI Treatment research. Please help us meet the $150,000 challenge offered by the Direct-MS Foundation.

Every dollar contributed by December 31, 2010 will be matched 1:1 by Direct-MS. Can you please help?

Sincerely yours,

Robert Zivadinov, MD, PhD

Director

P.S. Your gift for CCSVI research will, we firmly believe, provide the fastest way to answer these questions so important to everyone with MS and those who care for them.

------------------------------------------------------

?  Yes, I/we would like to help fund MS CCSVI Treatment Research. Enclosed is a check to Univ. at Buffalo for Buffalo Neuroimaging Analysis Center. To give by credit, debit card, or wire transfer, go to http://mstery.bnac.net/ for instructions. Online gifts through 12/31/10 will go to the CCSVI Treatment Research unless otherwise designated.

?  My/our gift of p $ 250 p $100 p $50 p $25 p Other received by 12/31/10 will be MATCHED $-FOR-$ by Direct-MS Foundation to help reach the $150,000 challenge goal!

Name ____________________________________________________________________

Address _________________________________________________________________

City________________________ State ________ Zip ________

Country ______________

Email _____________________________________

Daytime phone _______________________

?  This gift is eligible for a corporate matching gift. The authorization form will be sent to University at Buffalo Foundation Office c/o Cindy Johannes P.O. Box 730 Buffalo, NY 14226-0730

? Please contact me about gift questions.

The University at Buffalo is a 501(c) (3) Educational institution. Gifts are deductible according to IRS regulations.

http://www.facebook.com/note.php?note_id=173824599317809&id=100000920681513&ref=mf