Dr. Danna Spence at Michigan State University-
Dr.Spence's group was first to report that the RBCs obtained from people with type 2 (or adult-onset) diabetes released less ATP(50%) upon stimulation in comparison to RBCs obtained from non-diabetic subjects. The importance of this finding is due to the role of ATP in controlling blood flow, endothelial cell function, and platelet function.
When doing research on Red Blood Cells in subjects with MS it and found that blood samples from subjects with MS - have much higher levels of ATP (300% More) in their blood .

His research has shown when RBC's flow thru restrictive passages (as with CCSVI) they produce ATP- signaling for increasing NO2 ( Nitric Oxide ) in the blood.
This NO2 causes veins to dilate promoting easier passage for RBC's.

Unfortunately the NO2 leaks thru vein walls and damages (Inflammation) the Myelin on nerves (they run alongside the veins)promoting the Immune Cells to remove "defective" Myelin, leaving nerves even more exposed !

Normal NO2 levels,and in in less dilated veins' would prevent /reduce leakage and so Myelin inflammation.
Removing defective cells is normal for the immune system in MS , not a directed attack on myelin as in "EAE " where immune cells are produced that target even normal Myelin.

EAE - is a "Autoimmune Disease"that has been created injecting various myelin components into animal brains to provide differing myelin seeking immune cells for EAE and has misdirected research toward only different competing Immune Suppressing med's.

MS - is better labeled as a "Vascular Restriction Disease"

- that reduces blood draining from the CNS and causes Ruflux back to the brain - leaving inflammation producing Iron deposits.

The restricted RBC's produce - Very high levels of ATP causing - Very high amounts of NO2 leaking thru dilated vein walls to "Inflame" Myelin throughout the body, causing the Immune system to target the damaged cells.

This is just a normal function of the Imm.Sys. and depressing it - only Slows - it's Progress in MS.

Multiple amounts of restriction in different locations would produce toxic Iron deposits from Reflux with a variety of patterns of Plaques in the Brain.
And so the different types of MS and progression patterns as veins become restricted, intermittently reopened,or totally blocked throughout the CNS.

The greater the levels of Venous restriction - the higher the amounts of NO2 is produced because of higher levels of ATP with increased Myelin inflammation and targeting for it's removal.

This explains also,why all the Immune Suppressant MS med.'s help reduce ( the frequency ) of immune -"attack"- and only slowing the progress (for some) of MS.

The Neuro damage would then be "side effect" of 3-times the normal levels of NO2 stimulating ATP for years attempting to relieve restricted RBC's

All the-$-is in various competing drug research to suppress the Imm.Sys. while they only slow it's progress enough to help some.

If CCSVI Angioplasty treatment - reduces restrictions it would seem this would reduce ATP and so lower NO2 levels .

I should be standard to test ATP levels of all MS patients .
With ATP levels tested before and after CCSVI Angioplasty,with frequent monitoring to warn of returning blockage.

Patients suspected to have MS should have ATP levels tested before more $ expensive MRI tests are requested.
-doctors more willing to prescribe lower costing blood test-to screen for MRI & MRV (save $)
-everyone could be routinely have a blood test of ATP levels at a physical
-early CCSVI detection (or any venus restrictive problems)=less permanent damage