New research--hypoperfusion comes first in Alzheimer's
"... many lines of recent evidence also point towards a major importance of early cerebrovascular dysfunction at least for the most common form of the disease, sporadic AD. In the preclinical course not only neuronal but also vascular damage frequently occurs. Cerebral hypoperfusion, blood-brain barrier dysfunction and vascular oxidative stress are typical features of this stage of the disease. Most importantly, such alterations precede the classical pathological hallmarks, such as parenchymal deposition of extracellular amyloid and intracellular neurofibrillary tangles." http://www.ncbi.nlm.nih.gov/pubmed/23695007


[Vascular factors in the pathogenesis of Alzheime... [Nervenarzt. 2013] - PubMed - NCBI
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