Magnesium physiology and pathogenic mechanisms that contribute to the development of the metabolic syndrome (full paper)

“....Conclusion
In this review, we have presented a comprehensive discussion of the myriad of molecular and cellular mechanisms by which reduced Mg2+ status can elicit hypertension (endothelial dysfunction; smooth muscle contraction and remodeling), insulin resistance, impaired glucose tolerance, dyslipidemia, atheroma development, ischemic cardiomyopathy, increased adipocity, enhanced thrombosis, inflammation, and oxidative stress (summarized in figure 1). The causal mechanisms linking altered Mg2+ homeostasis and the metabolic syndrome clearly translate into clinical outcomes, increased incidence, as well as growing prevalence of the metabolic syndrome epidemic. While not impossible, pharmacologic prevention and management of the metabolic syndrome is difficult to attain, as numerous pharmacologic agents must be employed to control the bevy of cardiovascular disease and diabetes risk factors. Furthermore, given its pleiotropic impact on all components of the metabolic syndrome, Mg2+ seems like an ideal candidate to use in strategies aimed at preventing and controlling the syndrome. Future studies that elucidate, with great clarity, the large-scale impact of Mg2+ supplementation on the pathogenesis of the metabolic syndrome or its components are urgently needed. Consequently, clinical trials should be conducted to unequivocally confirm that Mg2+ therapy can prevent the development of the metabolic syndrome and its components in diverse at risk populations.”

source/learn more: http://www.jle.com/fr/revues/mrh/e-docs/magnesium_physiology_and_pathogenic_mechanisms_that_contribute_to_the_development_of_the_metabolic_syndrome_274667/article.phtml?tab=texte