Saturday, November 16, 2013 9:33 PM
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CCSVI in Multiple Sclerosis
NEW research--FULL paper. Endothelial specialists look at venous flow in MS and neurologic diseases. And these researchers say we're only at the beginning of understanding cerebral venous hemodynamics. (It ain't over MS specialists. Listen to phlebologists and vascular researcher.) "... a new hypothesis with more focus on the hemodynamic features of the cerebral and extracerebral venous system suggests that MS pathophysiology might be associated with the venous system that drains the CNS. Here, we present a comprehensive review of the pathophysiology of MS, ADEM, pseudotumor cerebri, and optic neuritis, with an emphasis on the roles of venous vascular system programming and dysfunction in their pathogenesis. We consider the fundamental differences between arterial and venous endothelium, their dissimilar responses to inflammation, and the potential theoretical contributions of venous insufficiency in the pathogenesis of neurovascular diseases." http://www.biomedcentral.com/1741-7015/11/219Venous endothelial injury in central nervous system diseaseswww.biomedcentral.com The role of the venous system in the pathogenesis of inflammatory neurological/neurodegenerative diseases remains largely unknown and underinvestigated. Aside from cerebral venous infarcts, thromboembolic events, and cerebrovascular bleeding, several inflammatory central nervous system (CNS) disease...
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