“Iron Deposition in the Gray Matter in Patients with Relapse-Remitting Multiple Sclerosis: A Longitudinal Study Using three-dimensional (3D)-enhanced T2*-weighted angiography (ESWAN)”
http://www.sciencedirect.com/science/article/pii/S0720048X15001874

EVERY part of Iron metabolism (Hephaestrin, Ferritin, Transferrin, Transportin, etc.) MUST HAVE bio-available Copper to work and without a sufficient amount of Ceruloplasmin there won't never be enough BOUND (bio-available) Copper the body can work with and to be able to produce such a sufficient amount of Ceruloplasmin (in the liver) the body needs (hint, hint..) sufficient amounts of Magnesium & real Vitamin C (no ascorbic acid!) as well!