“Neurovascular dysfunction, inflammation and endothelial activation: Implications for the pathogenesis of Alzheimer's disease” - via CCSVI in Multiple Sclerosis - Research into neurovascular diseases (like MS, Alzheimer's, Parkinsons) has viewed disease thru the narrow "neurocentric" view. But the brain is connected to the rest of the body. "In this review we summarize data that support a new paradigm of disease pathogenesis, based on endothelial dysfunction and release of pluripotent mediators with effects on inflammation, vascular activation/angiogenesis and neurotoxicity." http://www.jneuroinflammation.com/content/8/1/26