via CCSVI in Multiple Sclerosis - "Dr. Chaudhuri continues his research on MS as a disease of neurodegeneration and atrophy, not the immune system.

"The assumption of a primary immunopathogenesis of the disease is seriously flawed and has failed to deliver an effective therapy for most patients. The progressive degeneration of grey and white matter is integral to the natural history of the disease and is reflected in the atrophy of brain and spinal cord. Demyelination is an essential component of this primary neurodegenerative process rather than the target of a systemic immune response. The primary pathology of multiple sclerosis is a process of neurodegeneration based on the integrity of the blood-brain barrier."" http://www.ncbi.nlm.nih.gov/pubmed/23982272