From Dr. Zamboni -
First study in China confirms association between CCSVI and Multiple Sclerosis Dept. Neurology SunYatSen University

Abstract? Objective Chronic cerebrospinal venous insufficiency(CCSVI)is involved in pathogenetic mechanisms of multiple sclerosis(MS)and other inflammatory demyelinating diseases.However,CCSVI in MS and neuromyelitis optica(NMO)have not previously been investigated in China.Methods Ten MS patients,9NMO(and NMOSD)patients were enrolled.Extracranial venous ultrasonography was taken in all patients.Observation indexes including venous reflux,cross sectional area(CSA)of internal jugular veins(IJVs),and changes in IJVs CSA(?CSA).In addition,some of the patients underwent digital subtraction angiography(DSA)to detect stenosis of IJVs and azygous vein(AZY).Extracranial venous ultrasonography was also taken in 20age-match healthy controls.Results(1)Extracranial venous ultrasonography revealed that backstreaming in IJVs and vertebral vein(VVs)were significnatly associated with MS and NMO,and this association was much more significant in MS than NMO.CSA of IJVs on right-sidedness in sitting position of MS(P=0.028)and NMO(P=0.007)patients were obvious descend compared with controls.(2)DSA confirmed that narrow in VVs and collateral circulation were seen in MS and NMO patients.Conclusions Evaluated using ultrasonography and DSA,this study confirmed CCSVI in some MS and NMO patients.

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