Dr. P. Zamboni: "Paolo Zamboni @zambo57 https://twitter.com/zambo57 Neurology News Article | An ultrasound model to calculate the brain blood outflow through collaterals http://www.mdlinx.com/neurology/news-article.cfm/4723340?month Zamboni P et al. – The authors developed a novel model to calculate the cerebral venous return, normalized to the arterial inflow, in the different segments of the internal jugular vein (IJV). The preliminary application of the novel model in the clinical setting suggests the pivotal role of the collateral network in draining the blood into the superior vena cava under CCSVI condition. Paolo Zamboni (08/04/2013) comments: The cerebral venous rsystem is very complex. Posture, respiration, atmospheric, hydrostatic, and intracranial pressure are important motor mechanisms. In addition, the venous system is closely related to cerebrospinal fluid dynamics, as well as to the arterial and lymphatic system of tre head. Impaired cerebral venous return and the description of chronic cerebrospinal venous insufficiency (CCSVI) could open new perspectives in the understanding of neurodegenerative process, where a powerful regulator of chronic inflammation as the drainage is, is unfortunately not considered among the pathogenetic mechanisms of this group of diseases. The present article describes a reproducible non invasive US model to quantify the venous return from the brain, normalised to individual in-flow.. In CCSVI conditions the brain in-flow is mostly drained through veins collaterals, with consequent prolongation of the circulating time which in turn affects brain perfusion. In any neurodegenerative disease out of multiple sclerosis, the measurement herein described of extra cranial venous outflow from the brain should be added to the initial patient assessment."


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