Dr. Zamboni interview in "La Repubblica", by CCSVI in Multiple Sclerosis - facebook prikbord

This is a very important interview to read. It may not be what we want to hear, but it needs to be said. This is from Dr. Paolo Zamboni, the man who discovered CCSVI and continues to research how best to relieve venous stenosis and reflux. --

translation from Italian

May 24, 2011

Multiple Sclerosis, if it is the fault is of a vein --"Two years to verify my theory"

says Paolo Zamboni, the researcher who hypothesizes that involvement of the vein that goes from the heart to the brain, if decreased, would lead to the disease. But the scholar says: "it is advisable not to operate outside of clinical studies. Half of the patients' veins restenose"

http://www.repubblica.it/salute/medicina/2011/05/24/news/se_la_colpa_del_sistema_immunitario_due_anni_per_verificare_la_mia_teoria-16677023/

ROME - It is now clear that in the patient who suffers from multiple sclerosis the immune system attacks against the nervous system of the same individual. But what the trigger is, is not clear. Certainly, experts agree, there must be several causes. Based on the results of research conducted with its staff, Paolo Zamboni, director of the vascular diseases at the University of Ferrara, argues that one of these causes is a narrowing of the main veins that go from head to heart. Consequently, it is the stagnation of blood in the brain and toxic substances derived from metabolic processes that ultimately trigger self-aggression. Zamboni gives a metaphor : "If someone with multiple sclerosis is the victim, the murder weapon is the immune system, but the killers are still unknown. With our investigations we have collected enough evidence to put it a retainer, the narrowing of a vein, better known as Ccsvi, which stands for chronic cerebrospinal venous insufficiency. "

In the interview you granted us a year ago, you advised against venous dilation for patients, unless they are placed in a controlled trial, because there was still evidence of the effectiveness of the intervention. Do you not recommend it yet? "Of course. We have to wait a couple of years at least, when there should be the results of" Brave Dreams " study. This is multi-center research on 700 patients which is about to start. We are finishing the training of physicians in different centers who will do the ultrasound to find out if the patient has multiple sclerosis/Ccsvi and then the surgeons will operate. Some will not be operated on and blinded, and will not know whether the dilation was made or not. Then there will be at least one year of observation to see if there are improvements. "

Yet many patients are active seeking angioplasty immediately, often paying considerable sums of his own pocket. How do you stop this? "Ccsvi is not only fought with a dilated vein, and then we say goodbye to you. Ccsvi is an easy concept to understand but very difficult to treat. The number of relapses is high, but possible complications are rare. We have not finished our work in research in order to deliver a "turnkey" reliable method. For this reason, patients should be treated within studies created to protect them. "

Among the patients, after an improvement, many go back to as they were before. Why? "In about half of the patients, the operated venous constriction is formed again, and in these the symptoms recur. While this corrolation confirms the role of Ccsvi, other studies are used to improve the surgical technique. Angioplasty utilizes materials that were created to be valid on the veins, which have a different structure than arteries. and restenosis is also observed without any deterioration of multiple sclerosis. Although this is a fact it is difficult to interpret. Please note that in all patients we gave angioplasty did not stop the traditional immunosuppressive therapy, which could then prevent re-ignition of the disease. "

A study released early last year ECTRIMS Congress, doubts that the Ccsvi the cause of multiple sclerosis. "It is true, the data presented by Zivadinov in Buffalo is less exciting for us and does not help to understand if Ccsvi cause or epiphenomenon rather than MS. However, by assembling all of the research of this kind to date, we arrive at a series of 1,400 patients and 500 healthy controls, overall Ccsvi is present in 71% of patients and in 8% of healthy subjects. I believe these percentages are consistent with the hypothesis that the Ccsvi is among the causative factors of multiple sclerosis. "

(A. d'A.)

Source: http://www.facebook.com/notes/ccsvi-in-multiple-sclerosis/dr-zamboni-interview-in-la-repubblica/10150196089172211