BACKGROUND AND PURPOSE: CCSVI was recently described in patients with MS. CCSVI is diagnosed
noninvasively by Doppler sonography and invasively by catheter venography. We assessed the role of
conventional MRV for the detection of IJV anomalies in patients with MS diagnosed with CCSVI and
in healthy controls who underwent MRV and Doppler sonography examinations during 6 months.

MATERIALS AND METHODS: Ten patients with MS underwent TOF, TRICKS, Doppler sonography, and
catheter venography at baseline. They were treated at baseline with percutaneous angioplasty and
re-evaluated 6 months’ posttreatment with MRV and Doppler sonography. In addition, 6 healthy
controls underwent a baseline and a 6-month follow-up evaluation by Doppler sonography and MRV.

RESULTS: At baseline, the sensitivity, specificity, PPV, and NPV of Doppler sonography for detecting IJV
abnormalities relative to catheter venography in patients with MS were calculated, respectively, at 82%,
100%, 99%, and 95%. The figures were 99%, 33%, 33%, 99% for TOF and 99%, 39%, 35%, and 99%
for TRICKS. Venous anomalies included the annulus, septum, membrane, and malformed valve. No
agreement was found between TOF and catheter venography in 70% of patients with MS and between
TRICKS and catheter venography in 60% of patients with MS. At follow-up, 50% of the patients with MS
presented with abnormalities on Doppler sonography but only 30% were diagnosed with restenosis.

CONCLUSIONS: Conventional MRV has limited value for assessing IJV anomalies for both diagnostic

MRV has limited value for assessing IJV anomalies for both diagnostic
and posttreatment purposes.

FFor the complete study report go to:  http://www.ajnr.org/cgi/reprint/ajnr.A2386v1.pdf?maxtoshow&hits=1&RESULTFORMAT&andorexacttitle=and&andorexacttitleabs=and&fulltext=ccsvi&andorexactfulltext=and&searchid=1&usestrictdates=yes&resourcetype=HWCIT&ct