Pres. No.: P-237 - Evaluation of hemodynamic changes using dynamic susceptibility contrast-enhanced (DSC) MRI in patients with MS and Zamboni’s CCSVI

S. Marziali, F.G. Garaci, M. Melis, S. Fabiano, M. Stefanini, A. Meschini, M. 

Fornari, D. Centonze, R. Floris, G. Simonetti 

Rome/IT 

Purpose:

To evaluate cerebral hemodynamic changes using DSC-MRI in normal appearing white matter (NAWM) of multiple sclerosis (MS) patients with chronic cerebrospinal venous insufficiency (MS+CCSVI+), compared with MSpatients without CCSVI (MS+CCSVI-) and healthy subjects (controls).

Material and Methods:

From a series of MS patients enrolled by our institute and evaluated with color-Doppler-ultrasound (CDU) and phlebography, in order to establish the prevalence of CCSVI in MS we selected 42 patients: 32 satisfied the CDU criteria set by Zamboni et al. to diagnose CCSVI, 10 did not fall under those criteria. We evaluated a control group of 10 healthy subjects. Values of cerebral blood volume (CBV), cerebral blood flow (CBF) and mean transit time (MTT) were calculated in the semioval center, periventricular, frontal and peritrigonal NAWM. The perfusion data obtained in each area of NAWM were compared between the three groups.

Results:

Decreased CBV was observed in MS+CCSVI+ patients in the semioval center (p

peritrigonal p=0.008; periventricular p=0.008). Different MTT values were seen in the frontal NAWM (p=0.04), there were no differences in the remaining areas.

Conclusion:

MS+CCSVI+ patients show CBF and CBV anomalies at multiple levels in the NAWM, both with respect to controls and MS+CCSVI-. Despite these data seemed to be very interesting, further studies are needed on a larger study group.

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