Summary:
Chronic cerebrospinal venous insufficiency (CCSVI) has been suggested as a hypothesis explaining the development of multiple sclerosis (MS). In case reports, balloon dilatation of obstructed venous outflow has been successful and enthusiastic patient histories have given hope to MS patients. A systematic review of the evidence behind the pathophysiological hypothesis as well as concerning balloon dilatation does not support this form of treatment outside well designed trials.

David Bergqvist, Anders Wanhainen

Correspondence: David Bergqvist, Institutionen för kirurgiska vetenskaper, Akademiska sjukhuset, SE-751 85 Uppsala, Sweden
david.bergqvist@surgsci.uu.se

http://jobb.lakartidningen.se/artNo40140