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Wednesday, December 5, 2012 5:07 AM
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Ken Torbert
Disability caused by multiple sclerosis is associated with the number of extra cranial venous stenoses: possible improvement by venous angioplasty. Results of a prospective study
- M Denislic*?,
- Z Milosevic†,
- M Zorc*,‡,
- I Zuran D Ravnik*,‡ and
- O Mendiz§
+ Author Affiliations
- *MC Medicor, d.d., Tbilisijska 81
- †Clinical Centre Ljubljana, Institute of Radiology, Zaloska 7
- ‡University of Ljubljana, Medical Faculty, Korytkova 2, SI-1000 Ljubljana, Slovenia
- §Favaloro Foundation, Buenos Aires, Argentina
- Correspondence: Miro Denislic MD PhD
, Periceva 7, SI-1000 Ljubljana, Slovenia. Email: miro.denislic@gmail.com
AbstractObjective Chronic cerebrospinal venous insufficiency (CCSVI) was recently described in patients with multiple sclerosis (MS). The hypothesis of the vascular aetiology provides a new approach in the investigation and treatment of MS. Methods Our open-label study included 94 MS patients who fulfilled ultrasound sonographic criteria required for CCSVI. The internal jugular and/or azygous veins by a catheter venography were dilated. Results In 34.8% of the patients unilateral, in 65.2% bilateral venous abnormalities and in 2.1% no luminal obstructions were demonstrated. The patient group with the higher disability score had a significantly higher number of venous lesions (P < 0.005). Significant improvement of clinical disability in relapsing-remitting patients was (P < 0.001) achieved. In our study no stents were used. Re-stenosis occurred in 21.7% of the patients.
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