This was posted on This is Ms intresting.

Lancet Neurology has posted two very interesting reviews outlining the vascular connection to MS. The three main focuses are hypoperfusion, increased incidence of ischemic stroke, and the ischemic injury of the MS brain in white matter lesions and gray matter atrophy. CCSVI is also discussed as a possible mechanism of this vascular injury.

I've purchased both papers and written reviews of the research on Facebook.
https://www.facebook.com/note.php?note_ ... 0489747211

https://www.facebook.com/note.php?note_ ... 0373787211

For those not on Facebook and interested in purchasing the reviews for themselves...link below.
http://www.thelancet.com/journals/laneu ... 7/fulltext

The most interesting development is the change of heart for MS researcher Massimo Filippi, co-author of the first negative review of Dr. Zamboni published in the Annals of Neurology in Feb 2010.
http://onlinelibrary.wiley.com/doi/10.1 ... 1/abstract

Filippi now writes about the vascular aspects of MS, how the ischemic injury to brain tissue appears to be primary , and need for more research and clinical trials for CCSVI.

Quote:
For instance, in a combined perfusion and diffusion MRI study, there was an association between decreased perfusion and decreased mean diffusivity—a measure of tissue integrity—in the corpus callosum of patients with relapsing-remitting MS.7 This finding seems to be more consistent with what would be expected in primary ischaemia rather than as a result of secondary hypoperfusion associated with Wallerian degeneration.

Interesting times,
cheer