http://journals.tums.ac.ir/upload_files/pdf/_/15153.pdf

Abstract
The blood-brain barrier (BBB) is a complex organization of cerebral endothelial cells.
Deregulation of the BBB is among the earliest cerebrovascular abnormalities seen in
multiple sclerosis (MS).
Magnesium sulfate has been shown to have a protective effect on BBB integrity in
multiple experimental models. Magnesium sulphate attenuates BBB permeability. Also,
results of light microscopy and electron microscopy verified that magnesium sulfate can
attenuate BBB injury. I suggest using of MgSO4 which attenuates BBB permeability
during acute relapses of MS. The hypothesis should be assessed in several experimental
and clinical trials. If my hypothesis can be verified experimentally and clinically, then
using Mg sulphate to treat MS disease could be achieved.