Concepts of multiple sclerosis (MS) have shifted from the traditional view of a T cell-mediated, demyelinating disease of the white matter to include a broad range of immunopathogenic mechanisms, axonal damage, and widespread gray matter pathology. The cause of MS remains unknown, but recent epidemiological work has focused on genetic factors...and the controversial theory of chronic cerebrospinal venous insufficiency


Multiple Sclerosis: New Insights in Pathogenesi... [Annu Rev Med. 2011] - PubMed - NCBI
www.ncbi.nlm.nih.gov
PubMed comprises more than 21 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.