Hypoxia-like tissue injury as a component of multiple sclerosis lesions.
Lassmann H.
Author information

Division of Neuroimmunology, Brain Research Institute, University of Vienna, Spitalgasse 4, A-1090 Vienna, Austria. hans.lassman@univie.ac.at
Abstract
Recent data suggest that the mechanisms of demyelination and tissue damage in multiple sclerosis (MS) are heterogenous. In this review, evidence is discussed, which show that in a subset of multiple sclerosis patients the central nervous system (CNS) lesions show profound similarities to tissue alterations found in acute white matter stroke, thus suggesting that a hypoxia-like metabolic injury is a pathogenetic component in a subset of inflammatory brain lesions. Both, vascular pathology as well as metabolic disturbances induced by toxins of activated macrophages and microglia may be responsible for such lesions in multiple sclerosis.



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Is low perfusion from CCSVI the cause of hypoxia-like chronic brain injury?
Bassa perfusione da CCSVI: che sia lei il misterioso killer che crea lesioni ipossiche CEREBRALI nella SM?
http://www.ncbi.nlm.nih.gov/pubmed/12559509 — met Fiore Marco en 48 anderen.