The role of magnesium in traumatic CNS injury, by Naomi L. Cook, Frances Corrigan and Corinna van den Heuvel

“...Conclusions
Secondary injury factors involve numerous pathological processes that account for significant morbidity and mortality following traumatic CNS injury.
Deficits in intracellular Mg2+ concentration occurring following TBI and SCI are associated with poor neurological outcome, but despite promising experimental studies, Mg2+ has not been proven clinically effective. While it is unlikely that targeting a single factor will significantly improve neurological outcome, Mg2+ may still be a useful neuroprotective agent as part of a combination treatment regime that targets multiple components of the secondary injury cascade.”

source: http://universitypublishingonline.org/adelaide/aaa/chapter.jsf?bid=CBO9780987073051&cid=CBO9780987073051A020