Studies of prevalence show a great variability in prevalence of CCSVI in MS patients. However, a recent meta-analysis assessed an over 13 times increased prevalence in MS. Global hypoperfusion of the brain, and reduced cerebral spinal fluid dynamics in MS was shown to be related to CCSVI. Post-mortem studies show a higher prevalence of intraluminal defects in the main extracranial vein in MS patients in respect to controls.


ingentaconnect CCSVI is associated with multiple sclerosis
www.ingentaconnect.com
Keywords: Venous malformations; Multiple sclerosis; Echo color Doppler imaging; Brain circulation; Chronic cerebrospinal venous insufficiency