The Neurovascular Link in Health and Disease: Molecular Mechanisms and Therapeutic Implications

“...Conclusion and Outstanding Questions

The ‘‘neurocentric’’ viewpoint about neuro-degeneration and several other neurological disorders has prevailed for a long time. However, in the last two decades, the brain vasculature has increasingly entered the center stage as a key player that actively influences and directs brain development, homeostasis, and disease. Despite tremendous progress in understanding the functional properties of brain vessels in recent years, numerous questions remain unanswered. We will highlight here only a few examples. For instance, emerging evidence suggests that vessel growth in the brain relies in part on specific, perhaps even unique Proangiogenic signals. Identifying their molecular nature offers great promise to understand neurovascular disorders and to develop novel neurovascular medicine. Second, the role of pericytes has turned out to be more important than previously recognized. Do pericyte abnormalities causally contribute to neuro-degeneration and other types of neurological disorders, and can they be therapeutically targeted? Finally, the brain vasculature is now considered to be a major contributor of the neurogenic stem cell niche. Can this process be exploited for brain repair? Finding an answer to these and other questions promises to be a scientifically exciting journey with great translational potential...”

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The ‘‘neurocentric’’ viewpoint about neurodegeneration and several other neurological disorders has prevailed for a long time. However, in the last two decades, the brain vasculature has increasingly entered the center stage as a key player that actively influences and directs brain development, homeostasis, and disease.-- (just wanted to share this amazing paper.) http://sv.epfl.ch/files/content/sites/svnew2/files/shared/LSS%20Seminars/2014/Miguel-Aliaga_carmeliet.pdf