Friday, April 6, 2012 7:00 PM
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CCSVI in Multiple Sclerosis
This paper is from 1994, linked in yesterday's note. In 3 autopsy brains of those with acute MS, vascular changes and endothelial activation were noted before demyelination. "It is proposed that vascular endothelial cell activation may be an early and pivotal event in the evolution of multiple sclerosis, and that demyelination may have an ischaemic basis in this condition. The vascular endothelium may contain an early element in the evolution of multiple sclerosis." IT IS TIME TO UNDERSTAND CCSVI. Immunohistochemical study of vascular injury in acute multiple sclerosis. -- Wakefield et al. 47 (2)jcp.bmjjournals.com AIMS--To examine the vascular changes occurring in three archival cases of acute multiple sclerosis, and to provide immunohistochemical evidence of early endothelial cell activation and vascular occlusion in this condition. METHODS--Central nervous system tissues ...
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