New study from China: Susceptibility-weighted Imaging, MRV and PC-cine Studies of Healthy People and Patients with Multiple Sclerosis
Conclusion
1. In healthy controls, no significant difference was found between the deep cerebral venous phase value and age or gender and this result not only provide the reference of healthy people but also provide the basis that choosing the healthy controls needn’t limit their ages in the study. 2. The Acp value of deep cerebral veins in MS is higher than the controls, and the Acp value were increased in the review. This result implied the state of hypoxia of the brain parenchyma appeared in MS patients and the state of hypoxia would became more severe according to the course of desease. 3. The morphology grading of the veins showed significantly negative correlation with the veins phase value and the grading showed significantly correlation with veins phase value and lesion load. This result implied the veins morphology and brain lesion load were closed related to the state of hypoxia. 4. SWI offers a simple and noninvasive method that can be used as a routine clinical tool without the need for much image postprocessing. With markedly increased sensitivity in the detection of venous structures, SWI affords a noninvasive, albeit indirect way to qualitatively assess venous blood oxygenation, and subsequently disease burden. The information of venous structures and oxygen content may allow the clinician to closely monitor disease severity, progression, and response to therapies. 5. The morphology and hemodynamics of jugular veins in controls showed significant difference between sides and weak correlation was found between the morphology and aging. 6. There are significant difference of jugular veins morphology and hemodynamics between MS and controls and the study support the hypothesis that MS was related to the state of CCSVI.
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?Abstract in Chinese? ??????????????(Susceptibility-weighted imaging,SWI)???????(multiple sclerosis, MS)????????????????????????;??????????????????(three dimension phase contrast magnetic resonance venography,3D PC MRV)???????????,???????(MR phase-contrast cine, MR PC-cine)????????????,??MS?????????…