via CCSVI in Multiple Sclerosis - "Age-Related Vascular Differences Among Patients Suffering from Multiple Sclerosis"

New: Published study from cardiovascular team in Italy.

"552 multiple sclerosis patients tested using Dr. Zamboni's correct CCSVI protocol, in both supine and sitting positions. 458 (83%) showed alterations in the structures of cerebral veins and were divided in two different groups:
1) =30 (110 patients) and 2) >30 years old (348 patients).

Young patients showed a statistically significant higher number of both hemodinamically (44% vs 35%, p<0.01) and non-hemodinamically (51% vs 45%, p<0.05) significant stenosis in the internal jugular veins.

A lower percentage of young patients showed blocked outflow in the cervical veins (50% vs 65%, p<0.01) as compared to older. Patients >30 years old outlined a significant higher disability degree (Expanded Disability Status Scale score: 5 vs 3, p<0.01) as well as higher disease duration (12 vs 5 months, p<0.01) than younger."

What does this mean? CCSVI starts in young patients, and the change in jugular flow appears to lead to chronic, long-term changes in blood flow inside the brain, which is linked to disease progression, aging, and increase in EDSS.

"This could be due to the complex venous hemodynamic impairments induced by the alterations in vascular walls: the blocked or difficult blood flow through stenosis could increase the hydrostatic pressure in the skull and this could induce cerebral cells damages that could lead to the genesis of more advanced morphological abnormalities. Furthermore, the vessels' alterations could impair venous endothelial functions which could turn in a possible alteration of the controls of cerebral vein return which could worsen the cerebral vascular outflow. It may be possible that early clinical, pharmacological and/or invasive vascular interventions could exert a possible role in the natural history of multiple sclerosis course. Nevertheless, further trials are needed in order to confirm such considerations."
http://www.ncbi.nlm.nih.gov/pubmed/24274909


Age-Related Vascular Differences Among Pa... [Curr Neurovasc Res. 2013] - PubMed - NCBI
www.ncbi.nlm.nih.gov
PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.