Another new study show that people with Multiple Sclerosis have cerebral blood flow insufficiency due to deficits in cerebrovascular reactivity. http://www.ncbi.nlm.nih.gov/pubmed/27306754
What is cerebrovascular reactivity (also known as CVR)? Here is a blog post where I explain CVR, and cite other studies showing this vascular problem in MS. Columbia University has studied CVR and shown that it is related to endothelial dysfunction. More here: http://ccsviinms.blogspot.com/2015/02/putting-pieces-together.html

J Cereb Blood Flow Metab. 2016 Jun 15. pii: 0271678X16654922. [Epub ahead of print]