Researchers noted the venous changes in MS brains in 2008, using 7Tesla MRI (the most powerful, ultra high field equipment). They showed central veins in lesions and venous changes happening before the breakdown of the blood brain barrier. But there have be NO FOLLOW UP studies using 7T MRI. I heard Yulin Ge present on this research at an ISNVD conference--and can't help but wonder where is the curiosity? It's 2017. Onward.
In summary, our study, on the basis of increased detection of small and subtle perivenous or venous wall signal changes at 7T, attributable to high field strength, may represent, in fact, the earliest detectable vascular changes possible before BBB breakdown. The appreciation and assessment, in vivo, of early microvascular involvement in lesions is important in diagnosis, monitoring lesion progression, and determining therapeutic efficacy. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2579786/

Although the role of vascular pathology in multiple sclerosis (MS) lesions was suggested long ago, the derivation of these lesions from the vasculature has been difficult to assess in vivo. Ultra-high-field (e.g. 7T) MRI has provided an imaging tool for ...