New research on endoplasmic reticulum (ER) stress, elevated levels of protein Rab32, neurodegeneration and MS is in the press. http://www.telegraph.co.uk/news/2017/04/23/breakthrough-multiple-sclerosis-research-scientists-discover/ Lots of talk about "breakthroughs", "cause of disease!" and the hunt for ways to lower Rab32 levels. Missing from all the medical news- the point that (ER) is a vascular process already documented in vascular studies of disturbed blood flow and endothelial dysfunction. Healing the endothelium is the way to lower Rab32, decrease inflammation, decrease oxidative stress. It won't be a pill. #CCSVI #HeartBrainConnection #MSisVascular https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181710/

Prolonged perturbation of the endoplasmic reticulum (ER) leads to ER stress and unfolded protein response (UPR) and contributes to the pathogenesis of various chronic disorders. This review focuses on the role of ER stress and UPR in endothelial cells ...