Whether it's genetic or acquired is still to be determined, but the role of mitochondrial dysfunction in multiple sclerosis is evident. CNHS Board member, Dr. Bernhard Juurlink, also address this in his recent publication on pulse wave encephalopathy:

"There are a number of features of MS that suggest the immune response might be secondary to a degenerative event; these have been reviewed elsewhere [9-11]. In addition, neural cell mitochondrial dysfunction appears to play a significant role in the disease process [12], but whether this is primary or secondary is not clear. However, the incidence of MS, but not other autoimmune diseases, is very much greater in people with clinically-defined Leber’s hereditary optic neuropathy [13], a disease caused by mitochondrial mutations affecting mitochondrial Complex I function."

http://www.sciencedirect.com/science/article/pii/S0304394017305438