Molecular MRI of CNS endothelial cells is now a reality. This new technology allows researchers to see the process behind the break-down of the blood brain barrier. "Upon injury, the endothelial cells shift from a quiescent to an activated phenotype, involving increased vascular permeability, switch to a pro-thrombotic state, production of pro-inflammatory cytokines and exposure of adhesion molecules." #VascularConnectiontoMS #EndothelialHealthProgram

Endothelial cells of the central nervous system over-express surface proteins during neurological disorders, either as a cause, or a consequence, of the disease. Since the cerebral vasculature is easily accessible by large contrast-carrying particles, ...