Tuesday, March 1, 2016 1:12 AM
|
Venöse Multiple Sklerose, CVI & SVI, CCSVI
Here we go again. Iron overload & its impact on Ceruloplasmin in the middle of all those neurodegenerative conditions (not diseases!!). I'm really wondering whether these Neuroland-$marties do read their homemade science stuff at all. Doesn't seem so. Can't earn $$$ with a cure, can you? -- "Iron Efflux from Oligodendrocytes Is Differentially Regulated in Gray and White Matter", The Journal of Neuroscience, 2011 “...In summary, our data show that Heph is expressed by mature oligodendrocytes and plays a role in iron efflux from these cells. The findings presented here also indicate that white and gray matter oligodendrocytes can regulate iron efflux differently. We show that in the absence of Heph, white matter oligodendrocytes upregulate the expression of Cp, likely as a fail-safe mechanism. The lack of such compensatory upregulation of Cp in gray matter oligodendrocytes results in severe iron accumulation. We show that although oligodendrocytes have a high capacity to buffer excess iron, the increased iron load in gray matter oligodendrocytes leads to paranodal abnormalities that likely contribute to the motor deficits seen in the sla mutants. The present study reveals the first clear demonstration of a ferroxidase that is required for iron efflux from oligodendrocytes. This knowledge will help in future studies on iron homeostasis in various neurodegenerative diseases in which iron accumulation occurs...” full paper: http://www.jneurosci.org/content/31/37/13301.full
|