Vascular Disease in Multiple Sclerosis: A Real Thing?
Institute of Biostructures and Bioimaging, Italy, Oct. 2016

"...Macro and micro circulation alterations can cause changes in the endothelial cells, resulting in immune-mediated reactions and inflammatory response. The autoimmune inflammation can lead to iron deposition and leukocyte infiltration. Furthermore the consequent production of vascular mediators by the immune system cells and endothelial activation and neovascularization can cause changes in the microcirculation [35-38]. This multiple vascular risk factors together with inflammatory factors, through interactions with neuronal cells and components of myelin, could lead to increased permeability of the blood brain barrier and neurovascular uncoupling up to neuronal damage..."
learn more: http://www.omicsonline.org/open-access/vascular-disease-in-multiple-sclerosis-a-real-thing-2155-9864-1000370.php?aid=80646