Reciprocal Relationships Between Insulin Resistance and Endothelial Dysfunction

Molecular and Pathophysiological Mechanisms

"...Insulin Resistance Couples Vascular and Metabolic Pathophysiology
An important consequence of insulin action coupling hemodynamic and glucose homeostasis under healthy conditions is that in disease states, insulin resistance couples vascular and metabolic pathophysiology. Several distinct mechanisms work together to form a tight reciprocal relationship between insulin resistance and endothelial dysfunction. These include highly parallel insulin-signaling pathways controlling metabolic functions in skeletal muscle and production of NO in endothelium, reciprocal relationships between impaired insulin-stimulated blood flow and glucose uptake, metabolic and vascular consequences of pathway-specific impairment in insulin signaling, pathophysiological cross-talk between metabolic and vascular tissues mediated by hormones including angiotensin II and adiponectin, and shared stressors that individually contribute to insulin resistance and endothelial dysfunction..."

learn more: http://circ.ahajournals.org/content/113/15/1888