THE OXIDASE ACTIVITY OF SERUM CERULOPLASMIN IN MULTIPLE SCLEROSIS, The Psychoneurological Institute, Pruszkow, Poland. 1966
http://onlinelibrary.wiley.com/doi/10.1111/j.1600-0404.1966.tb01190.x/full#references

Transcript: Acta Neurol. Scandinav. 42, 379-384, 1966. From the Department of Neurology and Biochemical Laboratory of the Psychoneurological Insti tute in Pruszkow, Poland. THE OXIDASE ACTIVlTY OF SERUM CERULOPLASMIN IN MULTIPLE SCLEROSIS WOJCIECH CENDROWSKI and WACLAWA SZAJBEL INTRODUCTION Enzymatic activity of a number of oxidases in white matter, cerc- brospinal fluid and serum of multiple sclerotics is still a subject of research, because of its eventually significant role in the pathogenesis of the disease. Among these enzymes appears ceruloplasmin, a metalo- proteid with molecular weight 151.000, which occurs in serum alfaz- globulins and contains 0,34 per cent of copper, Abood et a f . (19571, Deufsch (1964), Houchin (1958), Markowifz e f a[ . (1955), Morel1 & Scheinberg (1960), Osaki e f al. (1964) and others. According to Jamie- son ( 1965), structural features of human ceruloplasmin adhere more closely to the pattern found in the majority of glycoproteins. This en- zyme catalyses the oxidation of poly-phenols, diamines and ascorbic acid. Some compounds as CN-, N3- and OCN- have inhibitory effects on the activity of ceruloplasmin. The biological function of ceruloplasmin is not completely understood although possibly it takes part in the ex- change of copper between the blood stream and different tissues. Since previous publications on the level of serum ceruloplasmin in multiple sclerosis are contradictory, dysproteinemia is a frequent find- ing in this disease, and the concentration of serum copper is of greater fluctuation than in control subjects, an attempt has been made â??to eva- luate the activity of ceruloplasmin in multiple sclerosis. The estimation of ceruloplasmin level may be important for better understanding of copper metabolism in multiple sclerosis. The copper plays a part in hio- logical respiration of myelin sheaths. I t is worth noting that in a previous paper on enzymatic activity of some transaminases and copper oxidase among patients with multiple sclerosis, in 3 cases lower levels of ceruloplasmin than in healthy sub- jects have been found, Cendrowski (1961). ....Learn more/transcript: https://dokumen.tips/documents/the-oxidase-activity-of-serum-ceruloplasmin-in-multiple-sclerosis.html

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