Thursday, December 28, 2017 7:30 AM
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Venöse Multiple Sklerose, CVI & SVI, CCSVI
H-ferritin ferroxidase induces cytoprotective pathways and inhibits microvascular stasis in transgenic sickle mice “...We conclude that wt-hFHC ferroxidase activity enhances cytoprotective Nrf2-regulated proteins including HO-1, thereby resulting in decreased NF-?B-activation, adhesion molecules, and microvascular stasis in transgenic SCD mice...” https://www.frontiersin.org/articles/10.3389/fphar.2014.00079/fullHemolysis, oxidative stress, inflammation, vaso-occlusion and organ infarction are hallmarks of sickle cell disease (SCD). We have previously shown that increases in heme oxygenase-1 (HO-1) activity detoxify heme and inhibit vaso-occlusion in transgenic mouse models of SCD. HO-1 releases Fe2+ from h...
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