Dysregulation of iron and copper homeostasis in nonalcoholic fatty liver [NAFLD], World J Hepatol. 2015

“...CONCLUSION
Elevated serum ferritin concentrations are a frequent finding in NAFLD. Excess iron is linked to IR, accelerated disease progression and adverse outcomes. Removing excess iron via phlebotomies is safe and has clinical benefits. We suggest that on the basis of available evidence it can be offered to NAFLD patients as it is linked to improvement of IR and inflammation. The mechanisms underlying iron accumulation in NAFLD are tightly linked to impaired iron export from liver cells as a consequence of low expression of the iron export molecule FPN and elevated hepcidin concentrations. Inflammation of adipose tissue as indicated by TNF-a and IL-6 and altered adipokine secretion (leptin, resistin) or hepcidin represent potent signals from diseased adipose tissue to dysregulate iron as well as glucose or lipid homeostasis.”
Full paper: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4342600/