Hypercalcemia and metastatic calcification

“...Vascular calcification
Small vessel calcification is the precursor of calciphylaxis, discussed above. It is partially reversible by parathyroidectomy in some patients, in contrast to large vessel calcification. An uncommon aspect is involvement of the penis, causing impotence and eventual gangrene. The prognosis of patients with widespread small vessel calcification in dismal. Linear calcification of medium and large arteries develops gradually during renal failure, causes narrowing of the lumen and ends in amputation for a significant minority of patients. Most authors identify high calcium phosphate product as the main aetiological factor in vascular calcification. Traditionally the product is of serum phosphate and total serum calcium though ionised serum calcium would be more logical. However several studies have shown no correlation [35, 36]suggesting that there are other important risk factors still to be discovered...”

full paper: https://academic.oup.com/cardiovascres/article/36/3/293/298591