Naar homepage     
Chronische Cerebro-Spinale Veneuze Insufficiëntie
Aanmelden op het CCSVI.nl forum
Lees Voor (ReadSpeaker)    A-   A+
Over CCSVI.nl | Zoeken | Contact | Forum
CCSVI.nl is onderdeel van de
Franz Schelling Website
meer informatie
  
Tuesday, November 27, 2018 1:10 AM | Venöse Multiple Sklerose, CVI & SVI, CCSVI Volg link
DON’T supplement/touch any none-food Iron except you want Cancer, Alzheimer D. etc. etc. on top of “MS”. Iron Deficiency Anaemia DOESN'T exist only Anaemia of Chronic Inflammation does, which is the OPPOSITE = toxic Iron overload in body tissue!

“Low Dose Iron Treatments Induce a DNA Damage Response in Human Endothelial Cells within Minutes, Research Article 2016

Abstract:

... Principal Findings
Rapid changes in RNA transcript profiles were observed in endothelial cells treated with 10µmol/L iron (II) citrate, compared to media-treated cells. Clustering for Gene Ontology (GO) performed on all differentially expressed genes revealed significant differences in biological process terms between iron and media-treated EC, whereas 10 sets of an equivalent number of randomly selected genes from the respective EC gene datasets showed no significant differences in any GO terms. After 1 hour, differentially expressed genes clustered to vesicle mediated transport, protein catabolism, and cell cycle (Benjamini p = 0.0016, 0.0024 and 0.0032 respectively), and by 6 hours, to cellular response to DNA damage stimulus most significantly through DNA repair genes FANCG, BLM, and H2AFX. Comet assays demonstrated that 10µM iron treatment elicited DNA damage within 1 hour. This was accompanied by a brisk DNA damage response pulse, as ascertained by the development of DNA damage response (DDR) foci, and p53 stabilization.
...Significance
These data suggest that low dose iron treatments are sufficient to modify the vascular endothelium, and induce a DNA damage response...”

full paper: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0147990
Low Dose Iron Treatments Induce a DNA Damage Response in Human Endothelial Cells within Minutes
Background Spontaneous reports from patients able to report vascular sequelae in real time, and recognition that serum non transferrin bound iron may reach or exceed 10µmol/L in the blood stream after iron tablets or infusions, led us to hypothesize that conventional iron treatments may provoke acu...